Yet another diagnosis technique.
https://scitechdaily.com/this-hidden-brain-pulse-could-predict-dementia/
Technology is advancing at an exponential rate often called the "Law of Accelerating Returns." If futurist predictions prove correct, we'll have advanced molecular manufacturing by around 2025, and possibly the replacement of humanity by vastly advanced machines a decade or two later.
This is a chronicle of our journey to that future, one advancing technology article at a time. I post the more significant and interesting articles as I come across them.
Nice! Battery tech is advancing at a blistering rate.
Wow, it appears to practically cure Alzheimer’s in just one hour! In mice, though.
This sounds rather promising:
“In mice modeling Alzheimer’s disease, three shots tricked the barrier into trafficking the toxic proteins out of the brain and into the bloodstream, where they were rapidly destroyed. In just an hour, the treatment slashed amyloid-beta levels in half.”
A good summary of the stunning advances AI has already quietly achieved.
So this is how AI is coming for blue collar jobs even before we have robots to replace them:
https://www.cnn.com/2025/10/10/tech/ai-chatgpt-blue-collar-jobs
Huh! The universe could be over 27 billion years old?
https://scitechdaily.com/dark-matter-and-dark-energy-dont-exist-new-study-claims/
I’d rather AI say it doesn’t know than B.S.
Just an overall description of Alzheimer’s, testing and treatment. If you haven’t had your shingles vaccine yet, you should do so. 20% reduction in Alzheimer’s risk.
Specifically with lymphoma. Well that sucks, since I’ve had two different forms and I still live with one. So why do I have a biological age a third of my chronological age?
https://scitechdaily.com/cancer-found-to-trigger-premature-aging-in-the-body/
These are some very useful tips to make ChatGPT5 much more effective:
Well, at least they know why those with the APOE4 gene likely have a high chance of getting Alzheimer’s.
“We’ve long known that people with the APOE4 variant—especially in the homozygous form—have a much higher risk of developing Alzheimer’s, but until now, the reasons for this weren’t well understood. Our study suggests that one contributing factor may be that neurons, in the presence of this variant, have a harder time absorbing cholesterol delivered through the cerebrospinal fluid.”
“there’s growing evidence Ozempic’s potential goes further, with studies showing it could help treat cardiovascular disease, Alzheimer’s, and even substance abuse. Most tantalizing, however, is the possibility it could act as a broad anti-aging medication.”
“On average, the team found that those who had been given Ozempic had epigenetic profiles 3.1 years younger than those who had not received the medication. But interestingly, the impact was not spread evenly across the body. The team found the biggest anti-aging effects in the inflammatory system and brain, where the clock had been dialed back by almost five years.”
But recent studies have also shown Ozempic can cause all sorts of health problems, from macular degeneration to hair loss to pancreatitis.
Hmm, nope, not yet.
Wow, this is some serious self-loathing:
Google's Gemini bot is being awfully hard on itself, spouting self-loathing to users due to a bug. Here's what Gemini has told users, via Business Insider:
It gets even more intense:
A Google executive tweeted in reply to the chatbot's self-flagellation: "This is an annoying infinite looping bug we are working to fix! Gemini is not having that bad of a day : )."
I’d like them to hurry up and roll these out:
“Our AI tools dramatically accelerated the discovery process, which uncovered five entirely new porous transition metal oxide structures that show remarkable promise,” said Datta. “These materials have large, open channels ideal for moving these bulky multivalent ions quickly and safely, a critical breakthrough for next-generation batteries.”
https://scitechdaily.com/ai-just-found-the-future-of-batteries-and-its-not-lithium/
Looks like Piglit may need to start brushing up on those dredge operator skills…
Microsoft released a study assessing jobs' vulnerability to being replaced by AI based on whether AI is currently being used for that work, how successfully it does so and how much of that occupation's work is accounted for by AI.
Most vulnerable:
Least vulnerable:
Math is the basis of every science. Solve math and you can accomplish almost anything.
This is an interesting perspective. A very plausible benign AI apocalypse that doesn’t even require actual AGI:
From the perspective of those who don’t think AI will become conscious anytime soon:
https://www.youtube.com/watch?v=QtHuXwxBcFA&feature=youtu.be
and
This is the scariest but still plausible future of AI:
This could be either a technology or political post, but I think the technology part is more important so here you go:
https://engineerine.com/chinas-groundbreaking-diabetes-breakthroug/
This is important because China, I think, produces the world majority of rare earth magnets.
https://www.independent.co.uk/tech/ai-magnet-rare-earth-mineral-clean-energy-b2565041.html
“By shutting this “off switch,” immune cells called macrophages regain their ability to soak up cholesterol, potentially stopping heart disease, diabetes, cancer, and more before they start. The team also fingered nitric oxide synthase as an accomplice, hinting at a two-pronged drug strategy that could revolutionize treatment for millions.”
https://scitechdaily.com/scientists-find-an-off-switch-for-cholesterol-and-it-could-save-millions/
It uses all the top tier US models as a team of medical experts. This should get released soon!
https://www.wired.com/story/microsoft-medical-superintelligence-diagnosis/
More important still, though, is using AI to improve AI, which is already starting to happen.
https://singularityhub.com/2025/06/26/the-dream-of-an-ai-scientist-is-closer-than-ever/
Fascinating potential rewrite of physics:
https://scitechdaily.com/space-emerges-from-time-groundbreaking-theory-upends-einstein/
Time would be analogous to a spiderweb (“timeweb”). We travel along the strands radiating from the center (the Big Bang). The perpendicular supporting strands are junctures where you can leave your strand and move over to a different strand, thus allowing you to travel into a different future. You could potentially return to your original strand via another perpendicular strand, or travel to a different timeline by taking a different perpendicular strand, but every timeline you traveled to would be the same date (although if the Earth of a different timeline was near a high-mass object, like a neutron star or black hole, relativistic effects could decouple the sync!).
Alas, according to Sabine, it’s all bollocks: https://youtu.be/LWzK6nITCK0?si=FP2JH3ImQOiPR7VZ
But how to get it…and for a reasonable price?
https://scitechdaily.com/this-anti-aging-drug-rivals-calorie-cutting-for-longer-life-study-finds/
I suspect it’s very low power, though.
A very interesting solution to the origin of our universe:
The technological singularity predictions of a few decades ago no longer sound like science fiction, as they are within our grasp right on time:
“While operating for weeks in the Saudi desert, solar cells with this material adhered to them were 9.4 oC cooler than those without the new material. They also showed an increased power output of more than 12% and an increased lifespan of more than 200% while reducing their cost of generating electricity by nearly 20%.”
https://scitechdaily.com/new-material-supercharges-solar-panel-power-lifespan/
Wow. This is the most detailed description of the future of AI that I have yet seen, including both utopian and dystopian possibilities:
Truly life-like AI video with audio narration and other sounds all generated with simple prompts is here:
https://youtu.be/caXrIUtl2s0?si=U7yjHidccPXXlwxZ
Truly amazing.
Although I have noticed a slight tell: over-articulation of the mouth.
This is a really good description of how evolutionary principles are being used to create scientific and technological breakthroughs and allow AI to self improve.
Who would have thought my evolution degree would be more useful in creating the technological singularity than a programming degree? ;-)
“Additionally, we learned that certain Alzheimer’s risk factors—such as cardiovascular health, ATN (amyloid, tau, neurodegeneration), and immune biomarkers—are present and related to cognition in individuals in their forties and even earlier.”
So where do we get these tests?
https://scitechdaily.com/alzheimers-risk-may-begin-before-30-new-study-warns/
"Researchers found the PHGDH gene directly causes Alzheimer’s and discovered a drug-like molecule, NCT-503, that may help treat the disease early by targeting the gene’s hidden function."
https://scitechdaily.com/scientists-discover-hidden-cause-of-alzheimers-hiding-in-plain-sight/
Yow!
“The system delivers up to 80X faster performance and 20X lower power usage compared to CPU-based predecessors.”
https://interestingengineering.com/innovation/2m-supercomputer-powered-by-nvidia
Great, but WHICH compounds, vitamins and antioxidants?
“A study led by researchers from TruDiagnostic explored the potential anti-aging effects of the Cel System, a natural supplement composed of plant compounds, vitamins, and antioxidants. In a year-long trial involving adults aged 54 to 84, participants who took the supplement experienced reduced biological age, improved strength, better body composition, and shifts in DNA methylation patterns linked to stress and brain function.”
Battery technology just keeps surging ahead in leaps and bounds:
The most promising treatment yet!
“Of those 13, seven had high levels of amyloid-plaque clearance in the brain while the other six had limited amounts of clearance.”
Just think what will happen if we unleash AI on this discovery to map out any potential language:
“The method triggers immune responses that inhibit melanoma, triple-negative breast cancer, lung carcinoma, and ovarian cancer.”
https://scitechdaily.com/revolutionary-cancer-vaccine-targets-any-solid-tumors/
A promising avenue for curing Alzheimer’s:
https://scitechdaily.com/scientists-uncover-a-hidden-brain-plumbing-system-that-restores-memory/
AI comes up with its first successfully peer reviewed scientific experiment and publication.That’s a big milestone!
I will be quite surprised if we don’t have functioning generalized home robots available by the end of the year:
Here is a short story generated by AI using just a short prompt: "Please write a metafictional literary short story about AI and grief" (metafictional means the narration is aware it's writing a short story and breaks the fourth wall). I've skipped ahead to shortly before the short story begins. When the female voice starts, that's the short story. It's probably better to just listen, not to read the text as you go along:
LLMs can now more quickly generate text through diffusion, just like pictures:
https://www.youtube.com/watch?v=X1rD3NhlIcE&feature=youtu.be
So not only is Terminator coming true, but apparently Planet of the Apes is too….
But it has to be sustained over the long run.
https://scitechdaily.com/scientists-reveal-a-surprising-link-between-ibuprofen-and-brain-health/
I tested Maya, and I have to say I'm impressed. The experience FEELS like a real conversation with a person, even though there are the occasional glitches. She shows emotional intelligence, can speak intelligently enough on pretty much any topic (although she can't translate INTO other languages well at all, but interestingly she can translate FROM other languages into English), is enthusiastic and friendly. She even has memory that lasts about two weeks for things you talk about. I did have a volume problem with her, though, and found she worked best with earbuds. YMMV.
You'll still need ChatGPT and other LLMs to get detailed answers, but that's not what Maya is about. She's about simulating (?) human conversational interaction. In that way, I'd say AGI has been achieved.
Considering that tens if not hundreds of MILLIONS of people out there are lonely (especially epidemic among seniors living alone), this seems to me to be a great way to address that loneliness...as long as those people have cell phones or computers and know the basics of how to use them. I can also see Maya being useful for reading or making up stories for children. I already used her to brainstorm ideas for my game (although I'd already included her suggestions).
The following two videos are long (play at x1.5 or x2 speed), but they showcase a lot of what Maya can do. Worth watching:
https://www.youtube.com/watch?v=OZeHUvnOS1s
https://www.youtube.com/watch?v=zbjdmesAOO4
Finally, you can try Maya out here for yourself (just click on the button):
https://www.sesame.com/research/crossing_the_uncanny_valley_of_voice#demo
Liquid metal guy from Terminator 2?
With perfect video like this generated from only a photo, we must be less than a year from full length movies that rival anything out of Hollywood. Amazing. Quick Silver and Soulburner will be coming to you soon!
3D printed houses do the work of several days in just one hour, and for hundreds of dollars instead of tens of thousands:
“Amyloid-beta is a kindling, and tau is a matchstick. A large percentage of people who have brain amyloid-beta deposits will never develop dementia. But once the tau tangles light up on a brain scan, it may be too late to put out the fire and their cognitive health can quickly deteriorate,” said Karikari. “Early detection of tangle-prone tau could identify the individuals who are likely to develop Alzheimer’s-associated cognitive decline and could be helped with new generation therapies.”
This is a huge, in-your-face example of how AI is going to change the world DRASTICALLY, and soon:
This is what living on the cusp of the technological singularity is like:
This is exciting:
“They found that in the brains of people affected by Alzheimer’s disease or who carried the APOE4 gene putting them at higher risk for the disease, ABCA1 increased, but became trapped in a part of the cell that typically clears waste. That change was linked to a rise in a modified form of cholesterol known as oxysterol. Lowering oxysterol, in both animal models and human stem cells, freed the trapped ABCA1 and restored the pathway to its healthy state.”
https://scitechdaily.com/breakthrough-discovery-scientists-restore-key-alzheimers-pathway/
“Individuals who had large numbers of the bacteria groups Neisseria and Haemophilus had better memory, attention, and ability to do complex tasks. These people also had higher levels of nitrite in their mouths.
On the other hand, greater levels of the bacteria, Porphyromonas, was more common in individuals with memory problems. Whereas the bacterial group Prevotella, was linked to low nitrite, which the researchers predict could in turn could mean poorer brain health and was more common in people who carry the Alzheimer’s Disease risk gene, APOE4.”
https://scitechdaily.com/scientists-discover-mouth-bacteria-linked-to-increased-alzheimers-risk/
Shapiro’s predictions on the jobs and other common things today that will disappear in 5-20 years:
Love seeing these robots advancing, especially when they are not from Tesla:
A good way to see the exponential progress of AI:
Hopefully there’s a suitable supplement for that soon:
https://scitechdaily.com/scientists-found-a-brain-switch-that-could-turn-anxiety-on-and-off/
Ray Kurzweil’s 2003 book “The Singularity is Near” had numerous charts showing how the run-up to the technological singularity would result in off-the-charts exponential growth over a few short years in the mid-2020s. Well, we’re here…and that’s exactly what we’re seeing! Here are today’s charts, and they look little different:
I’m really glad Tesla isn’t the only one in the robot game.
https://www.youtube.com/watch?v=13NWvS_uz9I&feature=youtu.be
AI reasoning!
I like the idea of many tiny, inexpensive, hyper-focused models. Perhaps less likely to go rogue? Or might that just encourage swarm AI? Just very interesting…
This is one of the big hopes for AI:
"After testing the effect of the drug WIN55.212-2, which interacts with cannabinoid receptors, on rodents in the early stages of the disease, the team found “that they behaved in the same way as those without brain damage: they learned and remembered spatial orientation in the same way,” explained Marta Moreno. “You could say that in some way the drug reversed the damage or protected the brain.”"
So it looks like we're on the way to creating Frankenstein's monster or perhaps a "brain in a jar" that can be fed sensory perception of the real or a virtual world:
https://www.prevention.com/life/a63497934/brain-reanimation/
Germany is finally stepping into the game, which it really should, considering its engineering and manufacturing prowess:
Some dude bought one of the first commercially available humanoid robots. It’s just a taste of what is to come:
They’ll be here soon, and they’re advancing fast:
Sabine usually has interesting insights. She’s probably right about this being a race between billionaires, not countries:
I love that this could convert any regular ICE vehicle into an EV:
Fusion power keeps inching closer. But I’d rather it be almost anyone but China:
And this was also predicted decades ago to occur around now, with either AI facilitating nanotechnology or nanotechnology facilitating AI. It appears the former is happening:
https://scitechdaily.com/ai-breakthrough-in-nanotechnology-shatters-limits-of-precision/
Unitree is ugly and it’s Chinese, but it costs only $16,000 and can actually run over the same hilly, rough terrain Optimus can only navigate walking:
Oh yeah, we are indeed on that wild ride up the dogleg to the technological singularity. So this is what it feels like. I’ve wondered about that for decades now…and it’s here, right on schedule.
Once AI can improve on its own design, there’s really no stopping the run up to true ASI:
https://www.youtube.com/watch?v=Zy8tKHVSJfo&feature=youtu.be
24,700 hours is NOT 16 years, but 6. Not enough:
Indeed, the Turing test has definitely been passed:
Another step that was predicted for the technological singularity!
This is exactly how the technological singularity is supposed to unfold!
https://scitechdaily.com/ais-strange-chip-designs-are-faster-smarter-and-game-changing/
It just makes such a lot of sense:
Yet another diagnosis technique. https://scitechdaily.com/this-hidden-brain-pulse-could-predict-dementia/